Join us

Director / Senior Director, DMPK

Job Summary

This influential position will report to the Chief Scientific Officer, and be responsible for conceiving and implementing the DMPK strategy for Aurons’ portfolio of targets driving cellular plasticity mechanisms for cancer. The individual will partner with key internal stakeholders and external consultants to characterize and optimize the pharmacokinetic and pharmacodynamic properties of Aurons’ small molecule compounds, as they progress towards the clinic.

Key responsibilities

Represent DMPK in supporting multiple projects from target identification to candidate selection, IND and into the clinic.

  • Represent DMPK across the portfolio, by developing and implementing appropriate DMPK strategies, designing nonclinical studies and interpreting/presenting data at cross-functional project teams
  • Work collaboratively with other core disciplines (medicinal chemistry, translational biology, toxicology and CMC) to support compound progression
  • Execute DMPK activities and experiments through external CRO’s and collaborators
  • Integrate data from multiple sources/ disciplines to build integrated exposure-effect relationships to inform on project strategy
  • Effectively communicate outcomes, interpretations and recommended paths forward to project team and Auron senior leaders
  • Contribute to the preparation and review of regulatory documents such as INDs


  • PhD, or equivalent experience, in relevant scientific discipline such as drug metabolism, pharmacology, pharmaceutical sciences, with at least 8 years of industry experience in DMPK
  • Broad and in-depth understanding of DMPK science, with an ability and eagerness to apply this to solving challenges
  • A strong analytical thinker, with a demonstrated expertise in PK optimization, and exposure-effect analyses. Able to build well rounded data packages to support compound progression.
  • An ability to partner with medicinal chemistry, translational biology and toxicology on overarching strategy through integration of DMPK data
  • Significant experience leading DMPK science from early lead finding through to candidate nomination and support of IND enabling studies. Ability to integrate preclinical PK and pharmacology data to project human PK and dose to guide optimization and candidate selection.
  • Experience of analyzing and interpreting early clinical data is a plus
  • Strong written and verbal communication skills with an ability to present data at the appropriate level with clear recommendations
  • Extensive experience of identifying the right CRO partners and managing them effectively
  • Someone who enjoys and thrives in a fast paced and dynamic small team environment

Apply Now

"*" indicates required fields

Max. file size: 128 MB.
Max. file size: 128 MB.