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Targeting
cell state plasticity
to improve patient outcomes in oncology and inflammatory disease

We aim to identify the root causes of disease
to deliver effective and durable therapies

Atlases to Map Cancer Cell States

We have combined a proprietary database of single cell genomic data with an AI/ML-powered computational platform that allows us to compare the normal healthy cell states of development to the dysfunctional cell states found in a range of human diseases. This mapping allows us to define the drivers of the diseased cell states and target these for therapeutic interventions.

A Diverse Team of Innovators

We have assembled a team with deep expertise in biology, medicinal chemistry, and computational science who work closely with leading physician-scientists.

Patient
Centered

At the center of everything we do are the patients. As pioneers in cell state drug development, we aim to offer patients longer, higher quality lives.

Our Team

Platform
Powered

Our AI-driven platform, AURIGINTM, allows us to identify cell state-specific targets, disease models , and biomarkers for efficient drug discovery and development.

Our Science

Product
Driven

Our pipeline is a direct result of our AURIGIN platform. Using AURIGIN, we are advancing programs designed to address the critical unmet needs in oncology and inflammatory disease.

Our Pipeline

An urgent unmet need

The initial indications of interest for our AUTX-703 are cancers with high U.S. mortality rates including:

21,000+ per year

Acute Myeloid Leukemia (AML)
  • Very rapidly growing cancer of the blood and bone marrow
  • Highly aggressive; poorly differentiated tumor
  • ~75% of patients relapsed / refractory
50%
of AML are driven by KAT2A/B
20%
Overall 5-year survival rate over 60 years old

30,000+ per year

Small-cell lung cancer (SCLC)
  • An aggressive, poorly differentiated, fast growing, highly metastatic tumor
  • SCLC is 15% of all lung cancers with limited treatment options
  • Initial sensitivity to chemotherapy, but most patients relapse in 3-6 months
70%
of SCLC tumors are driven by KAT2A/B
5-10%
Overall 5-year survival rate

15,000+ per year

Neuroendocrine prostate cancer (NEPC)
  • A highly aggressive subtype of prostate cancer; commonly arises in treatment-resistant patients
  • Limited / no treatment options
  • 15-20% of late-stage prostate cancer
60%
of NEPC tumors are driven by KAT2A/B
0-10%
Overall 1-year survival rate after diagnosis
SOURCES:
  1. US population incidence rates from American Cancer Society (2023)
  2. Cancer.org — Source
  3. Over 288K new cases of prostate cancer (PC) per year (Source - Cancer.org) and 0.5% to 2% of newly diagnosed PC are classified as NEPC (Source - NCBI)
  4. NCBI — Source
  5. Leukemia & Lymphoma Society — Source
  6. Leukemia & Lymphoma Society — Source

Focused Team.
One purpose.

We have fostered a culture that encourages our team to be curious, to think strategically and creatively, and to push the limits of science. We honor diversity and individuality, and are united by a single commitment to serve the patients and families who need new treatments.

Make an impact.

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Recent News

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March 26, 2025

Auron Therapeutics Announces Poster Presentation at 2025 AACR Annual Meeting

Newton, MA, March 26, 2025 – Auron Therapeutics, a clinical-stage biotechnology company targeting cell-state plasticity to improve patient outcomes in oncology and inflammatory disease, today announced that the Company will present updated preclinical data from its lead program, AUTX-703, during a poster session at the American Association for Cancer Research (AACR) Annual Meeting from April 25-30, 2025 in Chicago, IL.

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