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Targeting cell states in cancer
Mechanism of Action

Targeting Cancer Cell States

to Block Cancer Growth & Proliferation

In normal, healthy development, cells divide rapidly and proliferate to form the tissues and organs of the human body. Once these cells terminally differentiate, they are committed to a particular cell state and lose the ability to proliferate.

Genetic alterations have the potential to promote tumorigenesis – the process by which normal cells transform into cancer cells. These alterations hijack normal development pathways, pushing cancer cells into an earlier, proliferative cell state – also known as a plastic state. They do this by blocking terminal differentiation, inducing dedifferentiation (reversing a cell’s state to a less specialized and earlier cell state) or inducing transdifferentiation (the conversion of one cell state to another cell state).

The plastic states of cancer cells are associated with the most aggressive, metastatic, and drug-resistant tumors. By targeting the drivers that lock cancer cells in an altered cell state, we can revert the tumor cells back to their normal cell state and inhibit their growth and proliferation.

Our Platform

AURIGIN™ Platform

for Rapid Drug Discovery & Development

We have built a proprietary platform called AURIGIN that we are leveraging for the rapid discovery and development of the next generation of targeted cancer therapies.

AURIGIN is a proprietary platform that integrates our developmental biology expertise with AI Machine Learning algorithms. It includes a database of single cell genomics data that allows it to compare normal cell states to cancer cell states. The power of AURIGIN is its ability to harnesses novel insights into tumor biology and generate validated targets, identify optimized model systems for early program de-risking, and identify biomarkers for effective patient selection.

Our Pipeline

Pipeline Development

for the Next Generation of Targeted Cancer Therapies

We are developing a portfolio that is the direct output of our AURIGIN platform. We have identified a set of priority targets and programs that represent first-in-class or best-in-class opportunities for both solid tumor cancers and hematological malignancies.

  • Includes Breast Cancer, Non-Small Cell Lung Cancer, and Colorectal Cancer
  • Includes Neuroendocrine Prostate Cancer, Small Cell Lung Cancer, Neuroendocrine Tumors, and Neuroblastoma
  • EMT = Epithelial-Mesenchymal Transition
Publications & Presentations
March 26, 2024
Publication
Publication

Invasion of spontaneous germinal centers by naive B cells is rapid and persistent

Author(s)

M. R. Arbuckle, M. T. McClain, M. V. Rubertone, R. H. Scofield, G. J. Dennis, J. A. James, J. B. Harley

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Presented at

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AAAS Science journals are behind a paywall

Published in

AAAS: Science Immununology

March 23, 2024
Presentation
Presentation

Relatively Lengthy and Quite Descriptive and Scientific Title of the Presentation

Author(s)

Bob Hope, Carrie Underwood

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Presented at

JP Morgan Healthcare Conference 2024

Published in

March 21, 2024
Publication
Publication

Quite Descriptive and Relatively Lengthy and Scientific Title of the Publication

Author(s)

Andrew Garfield, Michelle Obama, Bill Murray, Franklin D Roosevelt, Mike Tyson

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Presented at

Published in

Nature

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Recent News

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March 6, 2024

Auron Announces Poster Presentations at 2024 AACR Annual Meeting

Auron Therapeutics, a biotechnology company focused on developing next-generation targeted therapies by identifying and inhibiting the oncogenic cell states of cancer, today announced that the Company will present an overview of its proprietary AURIGIN™ platform and the first preclinical data from its lead program during two poster sessions at the American Association for Cancer Research (AACR) Annual Meeting 2024.

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